In The First Descendant, you can search for and acquire many different weapons, but only a few belong to the best weapons in the game. We have looked through all the weapons and show you 5 of the best weapons you can find.
What kind of weapons are these? In this list, you will find the current 5 best weapons from The First Descendant. They are either extremely strong against bosses or will decimate large groups of enemies in a matter of seconds. Depending on which descendant you lead, one weapon or another might be worth it in your build.
We arrived at this selection through research from various sources – the results were then refined with our shooter expertise, which we bring from thousands of hours of play in Destiny 2 and Warframe.
We now present to you the 5 finalists in our list, explaining what you need for the weapons and what makes them so powerful. With our directory, you can quickly jump to the individual weapons:
Thunder Cage – Ultimate


Why is it so strong? This is a submachine gun of “Ultimate” rarity. The weapon is the perfect addition if you want to destroy many groups of enemies. With the effect “Electro Shockwave,” you have a 60% chance to trigger an electric shockwave after a kill that can damage other enemies within a radius of 3 meters.
What you need to build it:
- Polymer Syncytium (Thunder Cage)
- Synthetic Fiber (Thunder Cage)
- Nano Tube (Thunder Cage)
- Blueprint: Thunder Cage
Tamer – Rare

Why is it so strong? The Tamer is a rare machine gun without a strong ultimate effect. So the weapon does not convince with effects but with its damage, fire rate, magazine size, and the damage it can deal to vulnerable points. Additionally, the rifle can be farmed easily and does not have to be built.
Location: Must be farmed in the “Agna Desert” area in the “Remains” section through the battlefield mission: Abandoned Construction Site.
Enduring Legacy – Ultimate


Why is it so strong? The weapon “Enduring Legacy” is an “Ultimate” machine gun. The weapon impresses with its perk of status effects support. When you hit an enemy that is suffering from fire/cold/electric/poison, the triggering rate of the status effect is increased.
Additionally, enemies receive the debuff “Demoralize,” which makes them more susceptible to fire damage. As a final effect, the gun damage increases when you hit burning enemies with the MG.
What you need to build it:
- Polymer Syncytium (Enduring Legacy)
- Synthetic Fiber (Enduring Legacy)
- Nano Tube (Enduring Legacy)
- Blueprint: Enduring Legacy
Secret Garden – Ultimate


Why is it so strong? With the weapon “Secret Garden,” you hold a tactical rifle of “Ultimate” rarity in your hands. The rifle primarily supports tech and dimensional descendants, as using the aforementioned skills can either refill or even strengthen them – additionally, the effect “Pest Control” gives you an increased firearm damage that can stack up to 3x with the strengthening of your skills.
What you need to build it:
- Polymer Syncytium (Secret Garden)
- Synthetic Fiber (Secret Garden)
- Nano Tube (Secret Garden)
- Blueprint: Secret Garden
Smithereens – Ultimate


Why is it so strong? The Smithereens is a shotgun of “Ultimate” rarity and lives up to its name. The weapon focuses primarily on critical damage and can enhance it if you hit with all bullets in the chamber. The weapon is especially worth it for boss fights and descendants who specialize in critical hits.
What you need to build it:
- Polymer Syncytium (Smithereens)
- Synthetic Fiber (Smithereens)
- Nano Tube (Smithereens)
- Blueprint: Smithereens
Honorable Mentions that Didn’t Make the List
In addition to the best weapons in our list, there are also other adequate options that you can use in the fight against the aliens. The notable examples include the following weapons:
- Python – Submachine Gun (Ultimate)
- Withered Organ – Launcher (Legendary)
While the Python can primarily weaken your enemies as you shoot at critical points, the Withered Organ is a DPS monster. Equipped with Gley, you can melt bosses if you have the right skill active.
Which weapons do you think belong to the “Best Weapons” in The First Descendant? Feel free to share your opinion in the comments and discuss it with other users. You can find more about The First Descendant here: The First Descendant: Tier List – All Classes in Ranking