A new trailer shows in typical Fallout fashion how the building system in Fallout 76 works. It is designed to even protect you from atomic strikes.
In a new trailer “New American Dream,” presented at the Gamescom by Microsoft, you can see how the building system of Fallout 76 works. It explains how securing a base should work.
That bases in Fallout 76 are movable with the C.A.M.P. system was already known. The new trailer humorously illustrates that your constructed buildings and items can be secured and rebuilt elsewhere.

Importantly: This means that even the impact of an atomic missile in Fallout 76 does not irrevocably destroy your base. You can relocate your home at any time to a new position or rebuild it after destruction using saved templates.