Marguerite Baker from Resident Evil: Biohazard
Marguerite Baker, the wife of Jack Baker, is one of the main antagonists from Resident Evil 7. She initially appears as an older, somewhat weathered woman, but this changes at least in her boss fight.
Her arms and other limbs transform, becoming longer and more inhuman. Her belly consists of a disgusting insect nest, and she begins to crawl on the ceilings and walls like an oversized, thick bug.
In this form, she continuously attacks the player, only to retreat and then ambush again.
The sight of Marguerite is actually enough to recognize her as one of the most disgusting creatures of the franchise. The mix of body horror, with gross swarms of insects, and especially her movements make her the second place on this list. She is surpassed by a slightly younger but still disgusting colleague.
